Takashi Angata Selected Research

Sialic Acid Binding Immunoglobulin-like Lectins

1/2022	Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells.
1/2021	Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation.
1/2021	Recent Progress in the Methodologies to Identify Physiological Ligands of Siglecs.
1/2020	Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases.
1/2018	Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs.
1/2017	Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.
10/2015	Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.
9/2014	Associations of genetic polymorphisms of Siglecs with human diseases.
7/2014	Association of serum interleukin-27 with the exacerbation of chronic obstructive pulmonary disease.
2/2013	The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.

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Takashi Angata Research Topics

Disease

9	Neoplasms (Cancer) 01/2022 - 03/2009
4	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 07/2012
3	Hepatocellular Carcinoma (Hepatoma) 09/2013 - 01/2011
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2022 - 01/2022
2	Carcinoma (Carcinomatosis) 01/2021 - 07/2011
2	Infections 01/2018 - 06/2013
2	Autoimmune Diseases (Autoimmune Disease) 10/2015 - 09/2014
2	Bone Resorption 02/2015 - 12/2013
2	Emphysema 12/2013 - 07/2012
2	Liver Cirrhosis (Hepatic Cirrhosis) 06/2013 - 01/2011
2	Carcinogenesis 06/2013 - 03/2009
2	Disease Progression 07/2012 - 01/2011
2	Neoplasm Metastasis (Metastasis) 01/2011 - 03/2009
1	Atherosclerosis 01/2021
1	Guillain-Barre Syndrome 01/2021
1	Miller Fisher Syndrome (Fisher Syndrome) 01/2021
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2021
1	Communicable Diseases (Infectious Diseases) 01/2020
1	Osteoporosis 01/2020
1	Ankylosing Spondylitis 12/2019
1	Ankylosis 12/2019
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 12/2016
1	Cystic Fibrosis (Mucoviscidosis) 12/2016
1	Osteoarthritis 12/2016
1	Lymphoma (Lymphomas) 10/2015
1	Leukemia 10/2015
1	Postmenopausal Osteoporosis 02/2015
1	Insulinoma 09/2013
1	Inflammation (Inflammations) 04/2012
1	Chronic Disease (Chronic Diseases) 04/2012
1	Prostatic Neoplasms (Prostate Cancer) 07/2011
1	Transfusion Reaction 06/2011
1	Fibrosis (Cirrhosis) 01/2011
1	Hypoxia (Hypoxemia) 01/2011
1	Chronic Hepatitis (Chronic Active Hepatitis) 01/2011
1	Pancreatic Neoplasms (Pancreatic Cancer) 07/2010
1	Eosinophilia 05/2007
1	Pneumonia (Pneumonitis) 05/2007

Drug/Important Bio-Agent (IBA)

12	Sialic Acid Binding Immunoglobulin-like LectinsIBA 01/2022 - 05/2007
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 03/2009
8	Polysaccharides (Glycans)IBA 12/2016 - 03/2009
6	LigandsIBA 01/2022 - 05/2007
4	Biomarkers (Surrogate Marker)IBA 07/2014 - 04/2012
3	Glycoproteins (Glycoprotein)IBA 12/2016 - 01/2011
3	LectinsIBA 02/2015 - 01/2011
2	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2021 - 02/2015
2	EnzymesIBA 09/2014 - 01/2011
2	Pancreatic Elastase (Elastase)IBA 12/2013 - 07/2012
2	NucleotidesIBA 01/2011 - 07/2010
2	SugarsIBA 01/2011 - 07/2010
1	ibrutinibIBA 01/2022
1	LipidsIBA 01/2021
1	Apolipoproteins E (ApoE)IBA 01/2021
1	GangliosidesIBA 01/2021
1	AutoantibodiesIBA 01/2021
1	GlycosphingolipidsIBA 01/2021
1	Transcription Factors (Transcription Factor)IBA 12/2019
1	X-Box Binding Protein 1IBA 12/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2019
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 12/2019
1	Alkaline PhosphataseIBA 12/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 12/2016
1	Insulin-Like Growth Factor Binding ProteinsIBA 12/2016
1	Amyloid beta-PeptidesIBA 12/2016
1	Estrogens (Estrogen)FDA Link 02/2015
1	Immunoglobulins (Immunoglobulin)IBA 02/2015
1	Interleukin-27 (Interleukin 27)IBA 07/2014
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2013
1	LipopolysaccharidesIBA 12/2013
1	Tissue Inhibitor of Metalloproteinase-1IBA 12/2013
1	PerforinIBA 12/2013
1	Sialic AcidsIBA 09/2013
1	Cytidine Monophosphate (CMP)IBA 09/2013
1	AcidsIBA 09/2013
1	Culture MediaIBA 06/2013
1	GlycopeptidesIBA 06/2013
1	Biological ProductsIBA 02/2013
1	AntigensIBA 02/2013
1	sialosyl-Tn antigenIBA 02/2013
1	SmokeIBA 07/2012
1	Matrix Metalloproteinases (MMPs)IBA 07/2012
1	Tumor Biomarkers (Tumor Markers)IBA 04/2012
1	Monoclonal AntibodiesIBA 07/2011
1	IsoantibodiesIBA 06/2011
1	AcetylglucosamineIBA 01/2011
1	Glucose (Dextrose)FDA LinkGeneric 01/2011
1	GlycosyltransferasesIBA 01/2011
1	Uridine Diphosphate (UDP)IBA 07/2010
1	Guanosine Diphosphate (GDP)IBA 07/2010
1	AllergensIBA 05/2007

Therapy/Procedure

2	Therapeutics 10/2015 - 07/2011
1	Immunomodulation 10/2015
1	Aftercare (After-Treatment) 07/2012